Biosensor Development Service

Due to its unique advantages, the CRISPR-Cas system has been used to develop biosensors. CD BioSciences, a premier biotechnology company, is committed to providing you with CRISPR biosensor development service based on the CRISPR-Cas system.

Biosensors

A biosensor is an instrument used to detect the presence or concentration of biological analytes, biological structures or microorganisms. It consists of three main components: an identification element that identifies the analyte and generates a signal, a signal sensor, and a reader that measures and quantifies the received signal.

Biosensor

CRISPR-Cas System-Based Biosensors

The CRISPR-Cas system is an adaptive immune defense system for bacteria and archaea. It can be used not only for gene editing, but also shows great potential for analytes detection.

The discovery of the anticut properties of CRISPR V-type effectors has made the CRISPR-Cas system a potential high-precision biometric tool. In CRISPR biosensing technology, Cas effector proteins are used as highly specific In CRISPR biosensing, Cas effector proteins are used as highly specific sequence recognition elements, which can be used in combination with different biosensing mechanisms for rapid and sensitive detection of various analytes with high specificity.

Our Services

Utilizing the CRISPR-Cas system's ability to specifically identify and incidentally cleave, CD BioSciences offers biosensor development service for different detection needs. In addition, we also provide services for the detection of various analytes such as nucleic acids, protein biomarkers, metal ions, and small molecules.

Our DeteCas^TM platform offers diferent biosensors development service, including but not limited to the followings.

Nucleic Acid Biosensor Development Service

Constant Temperature Amplification of Target Nucleic Acids
Design of Efficient Signal Reporter Molecules
Preference of Cas Effector Proteins
Optimization of gRNA Design

Protein Biosensor Development Service

Design of dsDNA Containing T7 Promoter Sequence
Preference of Cas Effector Proteins
Design of DNA Activator
Selection of Different Signal Amplification Strategies

Metal Ion Biosensor Development Service

Design of Functional Nucleic Acids
Optimization of gRNA Design
Selection of Different Signal Amplification Strategies
Preference of Cas Effector Proteins
Design of DNA Activator

Small Molecule Biosensor Development Service

Designing Identification Components
Preference of Cas Effector Proteins
Optimization of gRNA Design
Design of Efficient Signal Reporter Molecules

Applications

Food Safety Detection

Disease Diagnosis

Environmental Monitoring

Process of Our Service

Advantages of Our Service

• High Flexibility

Only the given gRNA sequence needs to be changed for different gene targets.

• High Specificity

Single-base resolution detection of biosensors is fully possible.

• High Sensitivity

Target analytes can be detected at concentrations as low as 10^-18 mol/L.

CD BioSciences provides affordable, qualified and hassle-free biosensor development service to our global clients. We guarantee on-time delivery of results. We are available to you 24 hours a day, so please feel free to contact us.

References

Xu, W.J., et al. Pathogen detection based on CRISPR/Cas biosensing principal bacteria detection technology. Chinese Journal of Biological Engineering. 2021, 41(8): 8.
Xie, S.Y., et al. Advancing sensing technology with CRISPR: from the detection of nucleic acids to a broad range of analytes – A Review. Analytica Chimica Acta. 2021: 338848.
Chen, Y.J., et al. Applying CRISPR/Cas system as a signal enhancer for DNAzyme-based lead ion detection. Analytica Chimica Acta. 2021, (1192): 339356.

For research use only. Not intended for any clinical use.