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Due to its unique advantages, the CRISPR-Cas system has been used to develop biosensors. CD BioSciences, a premier biotechnology company, is committed to providing you with small molecule biosensor development service based on the CRISPR-Cas system.
In the life sciences, almost every cell contains hundreds of different organic molecules that play a key role in interspecies information exchange, cellular metabolism and regulation of transcriptional processes. In addition, many small molecules are contaminants of food and the environment. Therefore, the qualitative analysis and quantitative detection of small molecules are particularly important.
Utilizing the CRISPR-Cas system's ability to specifically identify and incidentally cleave nucleic acid sequences, CD BioSciences offers small molecule biosensor development service. In addition, we also provide services for the detection of various analytes such as nucleic acids, protein biomarkers, metal ions, and small molecules.
Our DeteCasTM platform offers different strategies in small molecule biosensor development service, including but not limited to the followings.
| Design of Identification Components | Selection of Cas Effector Proteins | |
| Transcription factors and functional nucleic acids can serve as recognition elements for CRISPR biosensors that specifically recognize and bind target small molecules. We can design different recognition elements according to your detection needs to improve recognition efficiency. | High quality Cas effector proteins are the basis for establishing high performance CRISPR-Cas biosensing systems. We can screen Cas effector proteins with excellent recognition efficiency and shear activity for you and shorten the detection time. | |
| Optimization of gRNA Design | Design of Efficient Signal Reporter Molecules | |
| The gRNA sequence characteristics and design location are critical factors in determining the specificity, loading, shear activity and stability of the CRISPR-Cas biosensing system. We can design different gRNA sequences for the gene targets of different nucleic acids to be tested to improve the detection specificity. | We can provide to design efficient signal reporter molecules based on the shear preferences of different Cas effector proteins, which facilitates the sensitivity of the sensing system. |
Food Safety Detection
Disease Diagnosis
Environmental Monitoring
• High Flexibility
Only the given gRNA sequence needs to be changed for different gene targets.
• High Specificity
Single-base resolution detection of biosensors is fully possible.
• High Sensitivity
Target analytes can be detected at concentrations as low as 10-18 mol/L.
CD BioSciences provides affordable, qualified and hassle-free small molecule biosensor development service to our global clients. We guarantee on-time delivery of results. We are available to you 24 hours a day, so please feel free to contact us.
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