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Rapid detection of analyte is essential for disease diagnosis, environmental and food safety monitoring. As a professional detection company, CD BioSciences is committed to providing efficient analyte detection service.
The CRISPR-Cas system is derived from the adaptive immune system of microorganisms such as bacteria, archaea and fungi, and consists of a combination of guide RNA and Cas enzymes. As an emerging technology in the field of biomolecules, it can be used as both a gene editing tool for precise manipulation and as a sensitive and efficient biosensing tool. In the field of bioanalysis, the CRISPR-Cas system has the advantage of precise targeting and efficient cleavage of targeted or non-targeted nucleic acids, and thus can be used for analyte detection, leading to applications in disease diagnosis, food safety and environmental contaminant monitoring.
The CRISPR-Cas9 system has the ability to precisely identify and cleave specific sequences and can be used as an auxiliary tool to cleave specific target sequences. Based on this property, CRISDA and CAS-EXPAR methods have been developed for highly sensitive detection of nucleic acids.
A novel peptide display technology, PICASSO, has also been developed to rapidly identify antibodies in clinical samples and can be used to detect protein biomarkers.
Two CRISPR-Cas12-based nucleic acid detection methods, DETECTR and HOLMES, were developed using the incidental cleavage activity of CRISPR-Cas12.
By using a fluorescent reporter system coupled with immobilized ATF(allosteric transcription factor), an efficient substance detection system, called CaT-SMelor, was developed for the detection of small molecules and metal ions using the trans cleavage activity of the CRIPSR-Cas system.
Two nucleic acid assays, SHERLOCK and SATORI, have been developed based on the incidental cleavage properties of CRISPR-Cas13. They can be used for outbreaks of viral and bacterial epidemics, monitoring antibiotic resistance, and detecting cancer.
The enzyme-linked immunosorbent assay using CRISPR-Cas13a as a signal amplification strategy is called CRISPR-Cas13a signal amplification combined immunosorbent assay, abbreviated as CLISA.
Utilizing the CRISPR-Cas system's ability to specifically identify and cleave nucleic acid sequences, CD BioSciences offer highly sensitive detection services for various analytes, such as nucleic acids, protein biomarkers, metal ions, and small molecules.
Our DeteCas™ platform can detect analytes in different origins and categories, including but not limited to the followings.
Small Molecule Detection Service
CD BioSciences provides affordable, qualified and hassle-free analyte detection service to our global clients. We guarantee on-time delivery of results. We are available to you 24 hours a day, so please feel free to contact us.
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