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Stomach Cancer Diagnosis

Gastric cancer is one of the common malignant tumors derived from gastric mucosa epithelial cells, and its morbidity and mortality ranks second among malignant tumors in the world.

Gastric Cancer Classification

Common Type Special Type
  • Tubular adenocarcinoma
  • Adenosquamous carcinoma
  • Poorly differentiated adenocarcinoma
  • Squamous cell carcinoma
  • Mucinous adenocarcinoma
  • Carcinoid
  • Signet ring cell carcinoma
  • Undifferentiated carcinoma
  • Gastric ulcer cancer

Stomach Cancer Diagnosis

The 5-year survival rate of early gastric cancer after treatment can reach more than 90%. Therefore, early detection and early treatment are essential to reduce the mortality rate of gastric cancer.

Conventional Diagnostic Methods

  • Imaging Examination
    Common imaging methods for gastric cancer include CT examination, upper gastrointestinal angiography (barium meal), B-ultrasound and magnetic resonance imaging.
  • Gastroscopy Examination
  • Gastroscopy Examination

Endoscopy is the most effective means of diagnosing gastric cancer. Not only can the location and shape of the lesion be visually seen, but also the lesion tissue can be directly taken for cytological and pathological examinations to obtain evidence of pathological diagnosis, and various treatments can be performed through gastroscope. In addition, endoscopy is also an important means and tool for gastric cancer screening.

  • Pathological Examination
    Pathological examination is the "gold standard" for the diagnosis of gastric cancer, and it is also an important diagnostic method for guiding treatment and judging prognosis.
  • Pathological Examination

Standard pathological diagnosis of gastric cancer includes gross anatomical findings (tumor size, growth pattern), depth of invasion, histological type, degree of differentiation, lymph node involvement, and immunohistochemical examination.

  • Laparoscopy and Peritoneal Lavage Cytology Examination
  • Laparoscopy can make up for the deficiencies of some laboratory tests and imaging examinations, re-identify clinical M (distant metastasis) and T (primary tumor) staging, avoid unnecessary laparotomy, and provide further diagnosis and treatment. reliable basis. In addition, while completing laparoscopic diagnosis, surgical treatment can also be completed within a certain range.

    The recurrence of intraperitoneal metastasis is the main cause of death in patients with gastric cancer, and the reason is the presence of free cancer cells in the abdominal cavity. Peritoneal lavage cytology is the "gold standard" for detecting free peritoneal cancer cells, and has become an important means of predicting "potential peritoneal metastasis".

Laboratory Examination

  • Fecal Silver Blood Testing
    It is a possible indication of early gastric cancer. About 30% of gastric cancer patients are positive for fecal occult blood.
  • Fecal Silver Blood Testing

  • Tumor Biomarkers Detection
    Tumor biomarkers refer to the substances synthesized and released by tumor cells or produced by the abnormal response of the body to tumors during the occurrence and proliferation of malignant tumors. The detection of a certain marker alone is often insufficient to determine the diagnosis of gastric cancer, and the combined detection is more meaningful than the single detection. At present, CEA, CA199, and CA724 are mostly used as the basis for clinical detection, and CA125, CA242 and other indicators are used for detection.

Tumor biomarkers of gastric cancer can be detected by line immunoassay (LIA), enzyme-linked immunosorbent assay (ELISA), and CRISPR molecular diagnostic techniques.

Our Services

Utilizing the DeteCasTM platform based on the CRISPR-Cas system, CD BioSciences can provide various services in stomach cancer diagnosis, such as nucleic acids detection service, protein biomarker detection service and small molecule detection service. If you are interested in these services, please contact us.

References

  1. Gholami, E., et al. Increasing the accuracy in the diagnosis of stomach cancer based on color and lint features of tongue. Biomedical Signal Processing and Control. 2021, 69(1):102782.
  2. Hiraoka, Y., et al. Appropriate Color Enhancement Settings for Blue Laser Imaging Facilitates the Diagnosis of Early Gastric Cancer with High Color Contrast. Journal of Gastric Cancer. 2021, 21(2).
For research use only. Not intended for any clinical use.

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